Efficacy Against Infectious Prions in Instrument Reprocessing

A 2005 study by Urs Rosenberg, PhD,1 addressed the effectiveness of cleaning processes in instrument washers, and at the same time, also explored the issue of prion contamination and decontamination.

Bovine spongiform encephalopathy (BSE), also known as Mad Cow disease or Scrapie in animals and variant Creutzfeldt Jakob disease (vCJD) in humans, is caused by prion proteins which are a so-called transmissible spongiform encephalopathies (TSEs).

Originating from English stock animals, the BSE crises spread into Western Europe, and today there have been verified cases in the United States and in Canada.

Contaminated bovine tissue BSE have transferred to humans, creating a new human TSE called variant CJD or simply vCJD. The accumulation pattern of infectious prion protein (PrPSc) in vCJD is different from the one in CJD; these vCJD prion proteins are found in the brain, lymph system, muscle, and blood, as well as other parts of the body.

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Source: Rosenberg study
March 2006

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